Dendrite nervous system11/11/2023 ![]() Dendrites were thought to convey electrical signals passively. This integration is both temporal – involving the summation of signals as well as spatial – entailing the aggregation of excitatory and inhibitory inputs from individual branches. Therefore, dendrites play a critical role in the integration of these inputs and in determining the extent of action potential generation.įurthermore, the structure and branching of dendrites together with the availability and variation in voltage-gated ion conductances strongly influences how synaptic inputs within a given microcircuit are integrated. The morphology and size of dendrites critically determines the mode of connectivity between neurons with dendritic trees ramifying in characteristic spatial domains where they receive specific synaptic inputs. They receive, integrate and process thousands of excitatory, and to a lesser extent inhibitory, synaptic inputs terminating either on the dendritic shaft or spine. ![]() Howard’s lab hopes that better understanding of branching at the cellular level will also shed light on these processes at the molecular and tissue levels.Dendrites (from Greek δένδρον déndron, “tree”) are one of the major structural elements of neurons and exhibit enormously diverse forms. There is a whole world of branching in biology, from the veins and arteries of the circulatory system to the bronchioles of the lung. “This means that now we can focus on the tips, because if we can understand how they work, then we can understand how the whole shape of the cell comes about,” says Howard. “We found that we can completely explain neuronal growth and the overall morphology in terms of just what the tips of the cells are doing,” says Sabyasachi Sutradhar, PhD, associate research scientist and joint lead author of the study. “And we found that no, they’re not inflating like a balloon, but rather growing and branching their tips.” “Before our study, there was a theory that neurons may be dilating and deflating like a balloon,” says Sonal Shree, PhD, associate research scientist and lead author of the study. Analysis of dendritic tips revealed their dynamic and stochastic (randomly determined) growth, which fluctuated among growing, shrinking, and paused states. But in as little as five days, they blossomed into big, tree-like structures with thousands of branches. In the earliest stages of development, the sensory neurons began with only two or three dendrites. After imaging the neurons at different stages of development, the team was able to create time-lapse movies of the growth. Because neurons reside just under the cuticle, the researchers were able to observe this process in real time in live larvae. To visualize this process, they tagged neurons with fluorescent markers and imaged them on a spinning disk microscope. The team studied neuronal growth in fruit flies as they matured from embryos into larvae. “We’re working on this branching process-how do branches form and grow? That is what’s underlying the whole way the nervous system works.” “Neurons are highly branched cells, and they’re like this because each neuron makes a connection with thousands of other neurons,” says Joe Howard, PhD, Eugene Higgins Professor of Molecular Biophysics and Biochemistry and professor of physics, and senior researcher of the study. Their findings are published in Science Advances. ![]() And now, Yale researchers have discovered the molecular mechanism behind the growth of this complex system. ![]() When the human brain develops, these structures branch out in a beautifully intricate, yet poorly understood, way that allows nerve cells to form connections and send messages throughout the body. Our nervous system is composed of billions of neurons that speak to each other through their axons and dendrites. ![]()
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